Journal: Chemotherapy
Submission Deadline: Closed
Optimization of antimicrobial therapy is essential for the improvement of the management and clinical outcomes of patients with infections. Antimicrobial therapy plays a critical role in treating severe infections and sepsis, and it is necessary to design appropriate antimicrobial dosing based on pharmacokinetic/pharmacodynamic (PK/PD) profiles. Sepsis can alter the distribution volume and clearance of antibiotics, leading to suboptimal or excessive antibiotic concentrations that can impact patient outcomes. The Surviving Sepsis Campaign recommends optimizing dosing strategies for antimicrobials by considering PK/PD and specific drug characteristics as a best practice procedure. To achieve this, therapeutic drug monitoring (TDM) is a strategy that quantifies drug concentrations in different biological samples.
Determining the plasma concentrations of a drug in the individual patient as a reference for possible dosage correction, TDM aims to maximize drug efficacy and minimize toxicity, thereby optimizing patient outcomes. TDM is increasingly being used for antiretrovirals, antibiotics, and antifungals and demonstrated to improve the likelihood of successful clinical outcomes, especially in cases involving drug interactions, pregnancy, or impaired liver and/or kidney function. This article collection on TDM in infectious diseases aims to improve our understanding of TDM's role in infection management and the effects of TDM-guided therapy on clinical outcomes, particularly in critically ill patients.
Authors should refer to the author guidelines. The manuscript submission deadline is September 30, 2024.
Please select the option “Call for Papers: Therapeutic Drug Monitoring in Infectious Diseases” when submitting your manuscript and mention this Call for Papers in your cover letter.
Chemotherapy supports Open Access publications. Corresponding authors can publish Open Access articles at no or reduced cost if they are associated with or employed by one of these universities/institutions.