Journal: Gerontology
Submission Deadline: May 15, 2025
Alzheimer’s disease (AD) is a complex neurodegenerative disorder, with increasing evidence highlighting the critical roles of infection and inflammation in its development and progression. We welcome submissions that explore the intricate connections between infections, chronic inflammation, and Alzheimer’s pathology.
Recent research suggests that microbial and viral pathogens may contribute to the accumulation of amyloid-beta, a protein central to AD that also serves as a potential antimicrobial agent. This dual role implies that amyloid-beta accumulation may initially act as a defence mechanism against brain infections but, when dysregulated, contribute to AD.
Neuroinflammation, driven by the brain’s immune response, is also recognized as a significant factor exacerbating neuronal damage and cognitive decline in AD. Chronic inflammation —not only localized within the brain but also peripheral inflammation— appears to play a pivotal role in disease progression, creating a vicious cycle of ongoing neurodegeneration.
We welcome original research, reviews, and case studies that investigate the interplay between infection and inflammation in AD. Topics of interest include, but are not limited to, the impact of specific pathogens, immune responses in AD, and novel therapeutic approaches targeting inflammation and infection in the context of AD.
Please select the option “Call for Papers: Infection and Inflammation in Alzheimer’s Disease” when submitting your manuscript and mention this Call for Papers in your cover letter.
Gerontology supports Open Access publications. Corresponding authors can publish Open Access articles at no or reduced cost if they are associated with or employed by one of these universities/institutions.
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